Zebra ZD400 series · Mid range
ZD421 Healthcare
Family of advanced 4-inch desktop printers purpose-built for healthcare: direct thermal, thermal transfer and ribbon cartridge.
They have disinfectant-ready white plastics, a UV-resistant enclosure, a sealed button interface and an IEC 60601-1 compliant power supply. They replace the GK Series and ZD420 Series. Print DNA makes setup and management easy, and PrintSecure helps protect against cyberattacks.
Variants
- ZD421 DT HC: Direct thermal; media 15–108 mm; 220.8 x 177.5 x 150.7 mm (L x W x H), 1.35 kg.
- ZD421 TT HC (roll ribbon): 300 m or 74 m ribbon, width 33.8–109.2 mm; media 15–112 mm; 267 x 202 x 189 mm, 2.05 kg.
- ZD421 RC HC (ribbon cartridge): 74 m cartridge ribbon, width 109.2 mm; media 15–118 mm; 254 x 202 x 177 mm, 2.3 kg. A smart chip in the ribbon signals when to change it.
- Print method
- Direct thermal, thermal transfer (roll ribbon) or ribbon cartridge (by model)
- Resolution
- 203 dpi; optional 300 dpi
- Print speed
- Up to 152 mm/s (203 dpi) and 102 mm/s (300 dpi)
- Print width
- Up to 104 mm (203 dpi) / 108 mm (300 dpi); 104 mm on the cartridge model
- Media
- Width up to 15–118 mm (by model); label length 6.4–991 mm; thickness 0.08–0.19 mm; roll OD up to 127 mm; core 12.7 mm and 25.4 mm (38.1, 50.8, 76.2 mm with adapters)
- Ribbon
- TT HC: 300 m or 74 m, width 33.8–109.2 mm; RC HC: 74 m cartridge, width 109.2 mm
- Connectivity
- Standard USB 2.0, USB Host, BLE 5 for setup; factory Ethernet 10/100 or 802.11ac Wi-Fi + Bluetooth 4.1; field Ethernet 10/100, 802.11ac Wi-Fi + Bluetooth 4.1, serial RS-232 (DB-9)
- Printer languages
- ZPL II, EPL 2, XML, ZBI, PDF Direct
- Memory
- 512 MB flash, 256 MB SDRAM; real-time clock
- Healthcare features
- White colour; IEC 60601-1 approved power supply; disinfectant-resistant plastics and sealed buttons; UV-resistant enclosure
- Options
- Dispenser/peeler and cutter (field)
- Operating temperature
- 4.4 °C to 41 °C
- Dimensions and weight
- DT HC: 220.8 x 177.5 x 150.7 mm, 1.35 kg; TT HC: 267 x 202 x 189 mm, 2.05 kg; RC HC: 254 x 202 x 177 mm, 2.3 kg
- Warranty
- At least 2 years
- Accessories
- Battery, carrying case, ZKDU, enclosed power supply for wireless setup

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Pricing
For enterprise hardware, price depends on quantity, configuration and service package. Add it to your quote list and we'll price it the same business day.
Use cases
- Prescription labels
- Laboratory and specimen labels
- Patient ID wristbands
- Blood and IV bag labels
- Patient record labels
- Asset labels
Not the right fit for
- Environments below 4.4 °C or above 41 °C: they fall outside the operating temperature range.
- Media wider than 118 mm: the widest media limit in the family is 118 mm.
- High-volume printing on the RC HC: the cartridge holds only 74 m of ribbon.
Common industries
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