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Zebra ZD400 series · Mid range

ZD421 Healthcare

Family of advanced 4-inch desktop printers purpose-built for healthcare: direct thermal, thermal transfer and ribbon cartridge.

They have disinfectant-ready white plastics, a UV-resistant enclosure, a sealed button interface and an IEC 60601-1 compliant power supply. They replace the GK Series and ZD420 Series. Print DNA makes setup and management easy, and PrintSecure helps protect against cyberattacks.

Variants

  • ZD421 DT HC: Direct thermal; media 15–108 mm; 220.8 x 177.5 x 150.7 mm (L x W x H), 1.35 kg.
  • ZD421 TT HC (roll ribbon): 300 m or 74 m ribbon, width 33.8–109.2 mm; media 15–112 mm; 267 x 202 x 189 mm, 2.05 kg.
  • ZD421 RC HC (ribbon cartridge): 74 m cartridge ribbon, width 109.2 mm; media 15–118 mm; 254 x 202 x 177 mm, 2.3 kg. A smart chip in the ribbon signals when to change it.
Print method
Direct thermal, thermal transfer (roll ribbon) or ribbon cartridge (by model)
Resolution
203 dpi; optional 300 dpi
Print speed
Up to 152 mm/s (203 dpi) and 102 mm/s (300 dpi)
Print width
Up to 104 mm (203 dpi) / 108 mm (300 dpi); 104 mm on the cartridge model
Media
Width up to 15–118 mm (by model); label length 6.4–991 mm; thickness 0.08–0.19 mm; roll OD up to 127 mm; core 12.7 mm and 25.4 mm (38.1, 50.8, 76.2 mm with adapters)
Ribbon
TT HC: 300 m or 74 m, width 33.8–109.2 mm; RC HC: 74 m cartridge, width 109.2 mm
Connectivity
Standard USB 2.0, USB Host, BLE 5 for setup; factory Ethernet 10/100 or 802.11ac Wi-Fi + Bluetooth 4.1; field Ethernet 10/100, 802.11ac Wi-Fi + Bluetooth 4.1, serial RS-232 (DB-9)
Printer languages
ZPL II, EPL 2, XML, ZBI, PDF Direct
Memory
512 MB flash, 256 MB SDRAM; real-time clock
Healthcare features
White colour; IEC 60601-1 approved power supply; disinfectant-resistant plastics and sealed buttons; UV-resistant enclosure
Options
Dispenser/peeler and cutter (field)
Operating temperature
4.4 °C to 41 °C
Dimensions and weight
DT HC: 220.8 x 177.5 x 150.7 mm, 1.35 kg; TT HC: 267 x 202 x 189 mm, 2.05 kg; RC HC: 254 x 202 x 177 mm, 2.3 kg
Warranty
At least 2 years
Accessories
Battery, carrying case, ZKDU, enclosed power supply for wireless setup
Zebra spec sheet (PDF) · Turkish
ZD421 Healthcare

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ZD421 Healthcare
ZD421 Healthcare

Pricing

For enterprise hardware, price depends on quantity, configuration and service package. Add it to your quote list and we'll price it the same business day.

Use cases

  • Prescription labels
  • Laboratory and specimen labels
  • Patient ID wristbands
  • Blood and IV bag labels
  • Patient record labels
  • Asset labels

Not the right fit for

  • Environments below 4.4 °C or above 41 °C: they fall outside the operating temperature range.
  • Media wider than 118 mm: the widest media limit in the family is 118 mm.
  • High-volume printing on the RC HC: the cartridge holds only 74 m of ribbon.

Common industries